Analysis of shared heritability in common disorders of the brain
Publication year
2018Author(s)
Number of pages
13 p.
Source
Science, 360, 6395, (2018), pp. |, article eaap8757ISSN
Publication type
Article / Letter to editor
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Organization
Human Genetics
Psychiatry
PI Group Memory & Emotion
Cognitive Neuroscience
Journal title
Science
Volume
vol. 360
Issue
iss. 6395
Page start
p. |
Subject
Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; Cognitive Neuroscience - Radboud University Medical Center; Human Genetics - Radboud University Medical Center; Psychiatry - Radboud University Medical CenterAbstract
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
This item appears in the following Collection(s)
- Academic publications [245050]
- Donders Centre for Cognitive Neuroimaging [4019]
- Electronic publications [132309]
- Faculty of Medical Sciences [93209]
- Open Access publications [105922]
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