Synthetic polymers as substrates for a DNA-sliding clamp protein
SourceBiopolymers, 109, 5, (2018), pp. e23119
Article / Letter to editor
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Physical Organic Chemistry
SubjectBio-Organic Chemistry; Molecular Materials; Physical Organic Chemistry; Radboudumc 19: Nanomedicine RIMLS: Radboud Institute for Molecular Life Sciences
The clamp protein (gp45) of the DNA polymerase III of the bacteriophage T4 is known to bind to DNA and stay attached to it in order to facilitate the process of DNA copying by the polymerase. As part of a project aimed at developing new biomimetic data-encoding systems we have investigated the binding of gp45 to synthetic polymers, that is, rigid, helical polyisocyanopeptides. Molecular modelling studies suggest that the clamp protein may interact with the latter polymers. Experiments aimed at verifying these interactions are presented and discussed.
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