Mosquito Infectivity and Parasitemia after Controlled Human Malaria Infection

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Title:	Mosquito Infectivity and Parasitemia after Controlled Human Malaria Infection
Author(s):	Walk, J.; Gemert, G.J. van ; Graumans, W.; Sauerwein, R.W. ; Bijker, E.M.
Publication year:	2018
Source:	American Journal of Tropical Medicine and Hygiene, vol. 98, iss. 6, (2018), pp. 1705-1708
ISSN:	0002-9637
DOI:	https://doi.org/10.4269/ajtmh.17-0952
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/193244
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Subject:	Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Medical Microbiology Amalia Childrens Hospital
Journal title:	American Journal of Tropical Medicine and Hygiene
Volume:	vol. 98
Issue:	iss. 6
Page start:	p. 1705
Page end:	p. 1708
Abstract:	Controlled Human Malaria Infection (CHMI) has become an increasingly important tool for the evaluation of drugs and vaccines. Controlled Human Malaria Infection has been demonstrated to be a reproducible model; however, there is some variability in time to onset of parasitemia between volunteers and studies. At our center, mosquitoes infected with Plasmodium falciparum by membrane feeding have variable and high salivary gland sporozoite load (mean 78,415; range 26,500-160,500). To determine whether this load influences parasitemia after CHMI, we analyzed data from 13 studies. We found no correlation between the sporozoite load of a mosquito batch and time to parasitemia or parasite density of first-wave parasitemia. These findings support the use of infected mosquito bite as a reproducible means of inducing P. falciparum infection and suggest that within this range, salivary gland sporozoite load does not influence the stringency of a CHMI.