Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder
Publication year
2018Author(s)
Source
Journal of Autism and Developmental Disorders, 48, 7, (2018), pp. 2490-2505ISSN
Publication type
Article / Letter to editor
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Organization
PI Group Memory & Emotion
Cognitive Neuroscience
Psychiatry
Journal title
Journal of Autism and Developmental Disorders
Volume
vol. 48
Issue
iss. 7
Page start
p. 2490
Page end
p. 2505
Subject
Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; Cognitive Neuroscience - Radboud University Medical CenterAbstract
Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.
This item appears in the following Collection(s)
- Academic publications [245131]
- Donders Centre for Cognitive Neuroimaging [4021]
- Electronic publications [132467]
- Faculty of Medical Sciences [93207]
- Open Access publications [106066]
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