Publication year
2007Author(s)
Number of pages
7 p.
Source
Age and Ageing, 26, 2, (2007), pp. 164-170ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
SW OZ DCC NRP
Journal title
Age and Ageing
Volume
vol. 26
Issue
iss. 2
Languages used
English (eng)
Page start
p. 164
Page end
p. 170
Subject
DI-BCB_DCC_Theme 3: Plasticity and Memory; Neuropsychology and rehabilitation psychology; Neuro- en revalidatiepsychologieAbstract
Background: exact mechanisms underlying cognitive dysfunction in diabetes mellitus (DM) remain unclear. Imaging studies of the brain could help to identify possible structural brain lesions underlying cognitive dysfunction.
Objective: to describe a detailed neuropsychological profile in patients functioning independently with type 2 DM. Secondly, correlations were studied between cognitive impairment and brain lesions on magnetic resonance imaging (MRI), i.e. periventricular hyperintensities (PVH), deep white matter lesions (DWML), medial temporal lobe atrophy (MTA), cerebral atrophy and lacunar infarcts. In addition, the influence of relevant disease variables of DM was studied.
Methods: 92 patients with type 2 DM (mean age 73.2 ± 5.7 years, mean duration 13.8 ± 10.8 years) and 44 control subjects (mean age 72.9 ± 5.3 years) were included and underwent an extensive neuropsychological test battery and an MRI of the brain.
Results: neuropsychological scores were worse for each cognitive domain except for memory functions after adjustment for hypertension in a group of elderly patients with type 2 DM compared to healthy control subjects. Only PVH were independently associated with motor speed, whereas all other MRI measures were not independently associated with cognitive impairment. Interactions between the different MRI measures were not present. Glycosylated haemoglobin (HbA1c) and duration of DM were significantly associated with cognitive dysfunction.
Conclusions: the data of this cross-sectional study show that type 2 DM is associated with diminished cognitive function in different cognitive domains, while memory is less affected after adjustment for hypertension. The association of cognitive impairment with MRI measures is equivocal, whereas HbA1c and duration of DM were significantly associated with cognitive dysfunction.
This item appears in the following Collection(s)
- Non RU Publications [16181]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.