Author(s):
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Hellbach, K.; Baehr, A.; Marco, F. De; Willer, K.; Gromann, L.B.; Herzen, J.; Dmochewitz, M.; Auweter, S.; Fingerle, A.A.; Noel, P.B.; Rummeny, E.J.; Yaroshenko, A.; Maack, H.I.; Pralow, T.;
Heijden, H.F.M. van der
; Wieberneit, N.; Proksa, R.; Koehler, T.; Rindt, K.; Schroeter, T.J.; Mohr, J.; Bamberg, F.; Ertl-Wagner, B.; Pfeiffer, F.; Reiser, M.F.
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Subject:
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Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc |
Abstract:
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The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 +/- 0.9) than in the transmission images (1.13 +/- 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.
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