Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

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Title:	Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers
Author(s):	Haigentz, M., Jr.; Suarez, C.; Strojan, P.; Rodrigo, J.P.; Rinaldo, A.; Bradford, C.R.; Corry, J.; Takes, R.P. ; Ferlito, A.
Publication year:	2018
Source:	Advances in Therapy, vol. 35, iss. 3, (2018), pp. 255-260
ISSN:	0741-238X
DOI:	https://doi.org/10.1007/s12325-018-0682-4
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/191264
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Subject:	Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Organization:	Otorhinolaryngology
Journal title:	Advances in Therapy
Volume:	vol. 35
Issue:	iss. 3
Page start:	p. 255
Page end:	p. 260
Abstract:	The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.