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Title: Nail Involvement in Alopecia Areata: A Questionnaire-based Survey on Clinical Signs, Impact on Quality of Life and Review of the Literature
Author(s): Roest, Y.B.M. ; Middendorp, H.T. van; Evers, A.W.M. ; Kerkhof, P.C.M. van de ; Pasch, M.C.
Publication year: 2018
Source: Acta Dermato-Venereologica, vol. 98, iss. 2, (2018), pp. 212-217
ISSN: 0001-5555
DOI: https://doi.org/10.2340/00015555-2810
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/190317   https://hdl.handle.net/2066/190317

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Subject: Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences
Radboudumc 2: Cancer development and immune defence RIHS: Radboud Institute for Health Sciences
Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences
Organization: Dermatology
Medical Psychology
Journal title:
Acta Dermato-Venereologica
Volume: vol. 98
Issue: iss. 2
Page start: p. 212
Page end: p. 217
Abstract:
Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes in patients with AA. This questionnaire-based survey evaluated 256 patients with AA. General demographic variables, specific nail changes, nail-related quality of life (QoL), and treatment history and need were evaluated. Prevalence of nail involvement in AA was 64.1%. The specific nail signs reported most frequently were pitting (29.7%, p = 0.008) and trachyonychia (18.0%). Red spots on the lunula were less frequent (5.1%), but very specific for severe AA. Nail-related QoL was only minimally affected by nail changes. In conclusion, nail involvement is common in patients with AA and presents mostly with pitting and trachyonychia. The presence of these nail changes reflects the severity of the disease, with red spots on the lunula as a predictor for severe alopecia.

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