2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
The Royal Society of Chemistry
SourceChemical Communications, 54, 25, (2018), pp. 3130-3133
Article / Letter to editor
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Synthetic Organic Chemistry
SubjectSynthetic Organic Chemistry
Prolyl hydroxylation of hypoxia inducible factor (HIF)-[small alpha], as catalysed by the Fe(ii)/2-oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia sensing role in animals. We report that binding of prolyl-hydroxylated HIF-[small alpha] to PHD2 is [similar]50 fold hindered by prior 2OG binding; thus, when 2OG is limiting, HIF-[small alpha] degradation might be inhibited by PHD binding.
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