2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
Publication year
2018Author(s)
Publisher
The Royal Society of Chemistry
Source
Chemical Communications, 54, 25, (2018), pp. 3130-3133ISSN
Publication type
Article / Letter to editor

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Organization
Synthetic Organic Chemistry
Journal title
Chemical Communications
Volume
vol. 54
Issue
iss. 25
Page start
p. 3130
Page end
p. 3133
Subject
Synthetic Organic ChemistryAbstract
Prolyl hydroxylation of hypoxia inducible factor (HIF)-[small alpha], as catalysed by the Fe(ii)/2-oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia sensing role in animals. We report that binding of prolyl-hydroxylated HIF-[small alpha] to PHD2 is [similar]50 fold hindered by prior 2OG binding; thus, when 2OG is limiting, HIF-[small alpha] degradation might be inhibited by PHD binding.
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