Variation in the serotonin transporter polymorphism (5-HTTLPR) and inertia of negative and positive emotions in daily life
Publication year
2018Number of pages
8 p.
Source
Emotion, 18, 2, (2018), pp. 229-236ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ BSI OGG
Journal title
Emotion
Volume
vol. 18
Issue
iss. 2
Page start
p. 229
Page end
p. 236
Subject
Developmental PsychopathologyAbstract
An important element of understanding the genotype-phenotype link in psychiatric disorders lies in identifying the psychological mechanisms through which genetic variation impacts mental health. Here we examined whether emotional inertia, the tendency for a person's emotions to carry over from 1 moment to the next and a prospective predictor of the development of depression, is associated with a known genetic risk factor for emotional dysregulation, a polymorphism in the serotonin transporter gene (5-HTTLPR). Two hundred thirty-six adolescents recorded their positive and negative emotions in daily life 9 times a day for 6 consecutive days using smartphones, completed a depression questionnaire, and were genotyped for the 5-HTTLPR polymorphism. Carriers of the short 5-HTTLPR were characterized by higher inertia for negative emotions, even after controlling for depressive symptoms. These findings suggest a possible psychological pathway how the serotonin transporter gene contributes to risk for depression.
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- Faculty of Social Sciences [27309]
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