Monochorionic dizygous twins presenting with blood chimerism and discordant sex
SourceTwin Research and Human Genetics, 16, 4, (2013), pp. 799-801
Article / Letter to editor
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Twin Research and Human Genetics
SubjectIGMD 1: Functional imaging; NCEBP 14: Cardiovascular diseases
Monochorionic dizygous twins are probably more frequent than considered previously as many cases remain unrecognized, especially when the children have the same sex. Here we present a pair of dizygous, sex-discordant monochorionic twins who were conceived after artificial insemination. Histological examination of the placenta and extensive genetic studies of the healthy boy and girl clearly proved that they indeed were monochorionic dizygous twins with a fully joined blood circulation. We conclude that when counseling parents expecting monochorionic twins of discordant sex, not only a disorder of sexual differentiation in one of the twins should be addressed but also the possibility of dizygosity with a completely normal (sexual) development of both children.
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