Influenza A virus induced bacterial otitis media is independent of virus tropism for alpha2,6-linked sialic acid.
SourceVirology Journal, 10, (2013)-128
Article / Letter to editor
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Paediatrics - OUD tm 2017
Laboratory of Genetic, Endocrine and Metabolic Diseases
SubjectIGMD 3: Genomic disorders and inherited multi-system disorders N4i 4: Auto-immunity, transplantation and immunotherapy; N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity
BACKGROUND: Otitis media (OM) affects >/=80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear. FINDINGS: Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to alpha2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of alpha2,6-linked sialic acid was not required to facilitate bacterial OM. CONCLUSIONS: Taken together, these data suggest that other features of the HA mediate bacterial OM.
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