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Title: Influenza A virus induced bacterial otitis media is independent of virus tropism for alpha2,6-linked sialic acid.
Author(s): Short, K.R.; Habets, M.N.; Payne, J.; Reading, P.C.; Diavatopoulos, D.A.; Wijburg, O.L.
Publication year: 2013
Source: Virology Journal, vol. 10, (2013)-128
ISSN: 1743-422X
DOI: https://doi.org/10.1186/1743-422X-10-128.
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/188710   http://hdl.handle.net/2066/188710

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Subject: IGMD 3: Genomic disorders and inherited multi-system disorders N4i 4: Auto-immunity, transplantation and immunotherapy
N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity
Organization: Paediatrics
Laboratory of Genetic, Endocrine and Metabolic Diseases
Journal title:
Virology Journal
Volume: vol. 10
Page end: p. 128
Abstract:
BACKGROUND: Otitis media (OM) affects >/=80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear. FINDINGS: Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to alpha2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of alpha2,6-linked sialic acid was not required to facilitate bacterial OM. CONCLUSIONS: Taken together, these data suggest that other features of the HA mediate bacterial OM.

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