DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.

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Title:	DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.
Author(s):	Geijtenbeek, T.B.; Vliet, S.J. van; Duijnhoven, G.C.F. van; Figdor, C.G. ; Kooyk, Y. van
Publication year:	2001
Source:	Placenta, vol. 22 Suppl A, (2001), pp. S19--23
ISSN:	0143-4004
DOI:	https://doi.org/10.1053/plac.2001.0674
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/188626
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Subject:	Tumorimmunology
Organization:	Tumorimmunology Human Genetics
Journal title:	Placenta
Volume:	vol. 22 Suppl A
Page start:	p. S19-
Page end:	p. 23
Abstract:	Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.