DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.
Publication year
2001Source
Placenta, 22 Suppl A, (2001), pp. S19--23ISSN
Publication type
Article / Letter to editor

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Organization
Tumorimmunology
Human Genetics
Journal title
Placenta
Volume
vol. 22 Suppl A
Page start
p. S19-
Page end
p. 23
Subject
TumorimmunologyAbstract
Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.
This item appears in the following Collection(s)
- Academic publications [203856]
- Faculty of Medical Sciences [80326]
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