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Title: A new facile method for spin-labeling of oligonucleotides.
Author(s): Strube, T.; Schiemann, O.; MacMillan, F.; Prisner, T.; Engels, J.A.
Publication year: 2001
Source: Nucleosides, Nucleotides and Nucleic Acids, vol. 20, iss. 4-7, (2001), pp. 1271-1274
ISSN: 1525-7770
DOI: https://doi.org/10.1081/NCN-100002534
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/188614   https://hdl.handle.net/2066/188614

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Subject: Public Health
Organization: Public Health
Journal title:
Nucleosides, Nucleotides and Nucleic Acids
Volume: vol. 20
Issue: iss. 4-7
Page start: p. 1271
Page end: p. 1274
Abstract:
A new facile method for spin-labeling suitable for DNA and RNA oligonucleotides is presented. The nitroxide 3-ethenyl-2,2,5,5-tetramethyl-pyrrolin-1-yloxy was directly introduced during automated solid-phase synthesis by a Pd(0) cross coupling reaction. The main advantages of this procedure are the small amount of spin-label needed for the derivatisation of the oligonucleotide and the high coupling efficiency on the solid phase.

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