No vasodilator response to low-dose heparin in the forearm skeletal-muscle vascular bed.
SourceEuropean Journal of Clinical Pharmacology, 58, 1, (2002), pp. 7-10
Article / Letter to editor
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European Journal of Clinical Pharmacology
SubjectEffects and kinetics of drugs in kidney and blood vessels; Hypertension and Circulation; Effecten en lotgevallen van geneesmiddelen in nier en bloedvaten; Hypertensie en circulatie
OBJECTIVE: Recent reports show that heparin induces vasodilation. This heparin-induced vasodilation might interfere with the results of vascular studies using the perfused-forearm technique because the arterial catheter is often flushed with a heparin solution in those experiments. Therefore, we investigated the vascular effects of flushing an arterial catheter with a heparin solution compared with a placebo solution (NaCl 0.9%) in six healthy volunteers. METHODS: During the first half of each experiment, the arterial catheter was flushed several times with the placebo solution. In the second half, identical flushes were performed with a solution of heparin diluted in NaCl 0.9% (4U x ml(-1)). RESULTS: Forearm blood flow (venous occlusion plethysmography) response was similar with heparin and placebo after all flushes. CONCLUSION: We conclude that low-dose heparin in the solution to flush an arterial catheter has no short-term vasodilator effect in the human forearm vascular bed. Therefore, the results of studies using the perfused-forearm technique are not confounded by flushes with a low-dose heparin solution.
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