(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6.
SourcePflügers Archiv : European Journal of Physiology, 446, 4, (2003), pp. 401-409
Article / Letter to editor
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Pflügers Archiv : European Journal of Physiology
SubjectUMCN 5.4: Renal disorders
The epithelial Ca(2+) channels TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) (re)absorption. These two members of the superfamily of transient receptor potential (TRP) channels were cloned from the vitamin-D-responsive epithelia of kidney and small intestine and subsequently identified in other tissues such as bone, pancreas and prostate. These channels are regulated by vitamin D as exemplified in animal models of vitamin-D-deficiency rickets. In addition, the epithelial Ca(2+) channels might be involved in the multifactorial pathogenesis of disorders ranging from idiopathic hypercalciuria, stone disease and postmenopausal osteoporosis. This review highlights the emerging (patho)physiological implications of these epithelial Ca(2+) channels.
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