Publication year
2003Source
Pflügers Archiv : European Journal of Physiology, 446, 4, (2003), pp. 401-9ISSN
Publication type
Article / Letter to editor

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Organization
Physiology
Journal title
Pflügers Archiv : European Journal of Physiology
Volume
vol. 446
Issue
iss. 4
Page start
p. 401
Page end
p. 9
Subject
UMCN 5.4: Renal disordersAbstract
The epithelial Ca(2+) channels TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) (re)absorption. These two members of the superfamily of transient receptor potential (TRP) channels were cloned from the vitamin-D-responsive epithelia of kidney and small intestine and subsequently identified in other tissues such as bone, pancreas and prostate. These channels are regulated by vitamin D as exemplified in animal models of vitamin-D-deficiency rickets. In addition, the epithelial Ca(2+) channels might be involved in the multifactorial pathogenesis of disorders ranging from idiopathic hypercalciuria, stone disease and postmenopausal osteoporosis. This review highlights the emerging (patho)physiological implications of these epithelial Ca(2+) channels.
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- Academic publications [227693]
- Faculty of Medical Sciences [86198]
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