Localised cutaneous microvascular adaptation to exercise training in humans.
Publication year
2018Source
European Journal of Applied Physiology, 118, 4, (2018), pp. 837-845ISSN
Annotation
01 april 2018
Publication type
Article / Letter to editor
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Organization
Physiology
Radboudumc Extern
Journal title
European Journal of Applied Physiology
Volume
vol. 118
Issue
iss. 4
Page start
p. 837
Page end
p. 845
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Physiology - Radboud University Medical CenterAbstract
PURPOSE: Exercise training induces adaptation in conduit and resistance arteries in humans, partly as a consequence of repeated elevation in blood flow and shear stress. The stimuli associated with intrinsic cutaneous microvascular adaptation to exercise training have been less comprehensively studied. METHODS: We studied 14 subjects who completed 8-weeks cycle ergometer training, with partial cuff inflation on one forearm to unilaterally attenuate cutaneous blood flow responses during each exercise-training bout. Before and after training, bilateral forearm skin microvascular dilation was determined using cutaneous vascular conductance (CVC: skin flux/blood pressure) responses to gradual localised heater disk stimulation performed at rest (33, 40, 42 and 44 degrees C). RESULTS: Cycle exercise induced significant increases in forearm cutaneous flux and temperature, which were attenuated in the cuffed arm (2-way ANOVA interaction-effect; P < 0.01). We found that forearm CVC at 42 and 44 degrees C was significantly lower in the uncuffed arm following 8-weeks of cycle training (P < 0.01), whereas no changes were apparent in the contralateral cuffed arm (P = 0.77, interaction-effect P = 0.01). CONCLUSIONS: Lower limb exercise training in healthy young men leads to lower CVC-responses to a local heating stimulus, an adaptation mediated, at least partly, by a mechanism related to episodic increases in skin blood flow and/or skin temperature.
This item appears in the following Collection(s)
- Academic publications [245262]
- Faculty of Medical Sciences [93208]
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