Treatment of refractory hand warts by isolated limb infusion with melphalan and actinomycin D.

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Title:	Treatment of refractory hand warts by isolated limb infusion with melphalan and actinomycin D.
Author(s):	Damian, D.L.; Barnetson, R.S.; Rose, B.R.; Bonenkamp, J.J. ; Thompson, J.
Publication year:	2001
Source:	The Australasian Journal of Dermatology, vol. 42, iss. 2, (2001), pp. 106--9
ISSN:	0004-8380
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/186955
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Subject:	Sepsis and non-bacterial generalized inflammation: causes and effects (sepsis and inflammation) Sepsis en niet-bacteriële gegeneraliseerde ontsteking: mogelijke oorzaken en gevolgen (sepsis en ontsteking)
Organization:	Surgery
Journal title:	The Australasian Journal of Dermatology
Volume:	vol. 42
Issue:	iss. 2
Page start:	p. 106-
Page end:	p. 9
Abstract:	We present an immunocompetent man with extensive warts on the hands, refractory to a number of conventional treatment modalities and causing substantial morbidity and impairment of normal function. Isolated limb infusion (regional intra-arterial chemotherapy) with melphalan and actinomycin D was performed, with substantial clearing of the warts within 2 months. Treatment-induced morbidity was limited to mild local erythema and oedema which resolved within 3 weeks. After 9 months' follow up, the patient had only a few residual warts and was able to resume normal activities.