The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells.

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Title:	The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells.
Author(s):	Lechmann, M.; Krooshoop, D.J.E.B.; Dudziak, D.; Kremmer, E.; Kuhnt, C.; Figdor, C.G. ; Schuler, G.; Steinkasserer, A.
Publication year:	2001
Source:	Journal of Experimental Medicine, vol. 194, iss. 12, (2001), pp. 1813-1821
ISSN:	0022-1007
DOI:	https://doi.org/10.1084/jem.194.12.1813
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/186936
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Subject:	Tumorimmunology Haematology
Organization:	Tumorimmunology
Journal title:	Journal of Experimental Medicine
Volume:	vol. 194
Issue:	iss. 12
Page start:	p. 1813
Page end:	p. 1821
Abstract:	CD83 is an immunoglobulin (Ig) superfamily member that is upregulated during the maturation of dendritic cells (DCs). It has been widely used as a marker for mature DCs, but its function is still unknown. To approach its potential functional role, we have expressed the extracellular Ig domain of human CD83 (hCD83ext) as a soluble protein. Using this tool we could show that immature as well as mature DCs bind to CD83. Since CD83 binds a ligand also expressed on immature DCs, which do not express CD83, indicates that binding is not a homophilic interaction. In addition we demonstrate that hCD83ext interferes with DC maturation downmodulating the expression of CD80 and CD83, while no phenotypical effects were observed on T cells. Finally, we show that hCD83ext inhibits DC-dependent allogeneic and peptide-specific T cell proliferation in a concentration dependent manner in vitro. This is the first report regarding functional aspects of CD83 and the binding of CD83 to DCs.