Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.

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Title:	Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
Author(s):	Riese, R.J.; Shi, G.P.; Villadangos, J.; Stetson, D.; Driessen, C.A.G.G. ; Lennon-Dumenil, A.M.; Chu, C.L.; Naumov, Y.; Behar, S.M.; Ploegh, H.L.; Locksley, R.; Chapman, H.A.
Publication year:	2001
Source:	Immunity, vol. 15, iss. 6, (2001), pp. 909--19
ISSN:	1074-7613
DOI:	https://doi.org/10.1016/S1074-7613(01)00247-3
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/186900
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Subject:	Hereditary and acquired vitreo-retinal disorders: experimental and clinical research and treatment. Erfelijke en verworven vitreo-retinale aandoeningen: experimenteel en klinisch onderzoek en behandeling.
Organization:	Ophthalmology
Journal title:	Immunity
Volume:	vol. 15
Issue:	iss. 6
Page start:	p. 909-
Page end:	p. 19
Abstract:	NK1.1(+) T cells develop and function through interactions with cell surface CD1 complexes. In I-A(b) mice lacking the invariant chain (Ii) processing enzyme, cathepsin S, NK1.1(+) T cell selection and function are impaired. In vitro, thymic dendritic cells (DCs) from cathepsin S(-/-) mice exhibit defective presentation of the CD1-restricted antigen, alpha-galactosylceramide (alpha-GalCer). CD1 dysfunction is secondary to defective trafficking of CD1, which colocalizes with Ii fragments and accumulates within endocytic compartments of cathepsin S(-/-) DCs. I-A(k), cathepsin S(-/-) mice do not accumulate class II-associated Ii fragments and accordingly do not display CD1 abnormalities. Thus, function of CD1 is critically linked to processing of Ii, revealing MHC class II haplotype and cathepsin S activity as regulators of NK T cells.