Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report.
SourceEuropean Journal of Pain, 5, 3, (2001), pp. 325--31
Article / Letter to editor
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European Journal of Pain
SubjectControl Systems in Anaesthesiology; Sturingssystemen in de anesthesiologie
Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 microg/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1-2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness.
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