SourceNucleosides, Nucleotides and Nucleic Acids, 20, 4-7, (2001), pp. 481--6
Article / Letter to editor
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Nucleosides, Nucleotides and Nucleic Acids
Integration of the proviral DNA into the genome of infected cells is a key step of HIV-1 replication. Integration is catalyzed by the viral enzyme integrase (IN). 6-oxocytidine-containing oligonucleotides were found to be efficient inhibitors of integrase in vitro. The inhibitory effect is sequence-specific and strictly requires the presence of the 6-oxocytidine base. It is due to the impairment of the integrase binding to its substrate and does not involve an auto-structure of the oligonucleotide.
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