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Title: Pathologic staging of melanoma.
Author(s): Ruiter, D.J. ; Spatz, A.; Oord, J.J. van den; Cook, M.
Publication year: 2002
Source: Seminars in Oncology, vol. 29, iss. 4, (2002), pp. 370-381
ISSN: 0093-7754
DOI: https://doi.org/10.1053/sonc.2002.34116
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/186642   http://hdl.handle.net/2066/186642

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Subject: Tumor pathology
Tumor pathologie
Organization: Pathology
Journal title:
Seminars in Oncology
Volume: vol. 29
Issue: iss. 4
Page start: p. 370
Page end: p. 381
Abstract:
The American Joint Committee on Cancer (AJCC) recently launched a new staging system for cutaneous melanoma that was based on clinical experience with a large number of patients treated in major centers worldwide. As this system includes various histopathologic parameters of the primary melanoma and of melanoma metastasis, including micrometastases in the sentinel lymph node (SLN), they are discussed here. Special attention is given to ulceration of the primary tumor, because it remains a dominant prognostic parameter in addition to tumor thickness. Molecular markers that may reflect aggressive behavior of the primary melanoma also are described. Finally, pathologic examination of SLNs is addressed with emphasis on the efficacy of various microstaging approaches.

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