MMP9 potentiates pulmonary metastasis formation.
SourceCancer Cell, 2, 4, (2002), pp. 251-252
Article / Letter to editor
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SubjectTumor pathology; Tumor pathologie
Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).
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