Gut hormones in preterm infants with necrotizing enterocolitis during starvation and reintroduction of enteral nutrition.

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Publication year
2002Source
Journal of Pediatric Gastroenterology and Nutrition, 35, 5, (2002), pp. 674-679ISSN
Publication type
Article / Letter to editor

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Organization
Gastroenterology
Journal title
Journal of Pediatric Gastroenterology and Nutrition
Volume
vol. 35
Issue
iss. 5
Page start
p. 674
Page end
p. 679
Subject
Metabolic aspects of gastrointestinal diseases; Metabole aspecten van maag-, darm- en leveraandoeningenAbstract
OBJECTIVES Gastrointestinal hormones control gut functions in response to enteral nutrition. Diseases involving the gastrointestinal tract, such as necrotizing enterocolitis, may affect gut hormone secretion and therefore influence gut functions. Because bowel rest is an important part of the treatment, infants with this disease are especially at risk for an altered gut hormone secretion and thus for compromised gut functions.METHODS In the current study, the gastrointestinal hormone profiles of eight preterm infants with an ileostomy after necrotizing enterocolitis (Bell stages 2 and 3) were evaluated during starvation and reintroduction of enteral nutrition. Basal and postprandial plasma concentrations of gastrin, cholecystokinin, and peptide YY were measured with sensitive and specific radioimmunoassays. The results were compared with those of 11 controls.RESULTS In the patients and the controls, plasma concentrations of all hormones were higher postprandially. The increases in cholecystokinin and peptide YY were significant in the patients. Compared with the controls, all concentrations were higher in the patients, and changes were significant for basal and postprandial cholecystokinin and postprandial peptide YY.CONCLUSIONS Enteral nutrition stimulates the secretion of gastrointestinal hormones, also in premature infants with a diseased distal small bowel and colon, as in necrotizing enterocolitis. The postprandial increase of peptide YY in patients with an ileostomy indicates that enteral substrate in the colon is not necessary for stimulation of peptide YY secretion.
This item appears in the following Collection(s)
- Academic publications [204968]
- Electronic publications [103216]
- Faculty of Medical Sciences [81049]
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