Autoinhibition of c-Abl.
SourceCell, 108, 2, (2002), pp. 247-59
Article / Letter to editor
Display more detailsDisplay less details
Cell Biology (UMC)
SubjectStudy of abnormal differentiation and transformation processes in heritable and acquired disorders with the use of cell and animal models; Bestudering van abnormale differentiatie en transformatieprocessen bij erfelijke of verworven aandoeningen m.b.v. cel- en diermodellen
Despite years of investigation, the molecular mechanism responsible for regulation of the c-Abl tyrosine kinase has remained elusive. We now report inhibition of the catalytic activity of purified c-Abl in vitro, demonstrating that regulation is an intrinsic property of the molecule. We show that the interaction of the N-terminal 80 residues with the rest of the protein mediates autoregulation. This N-terminal "cap" is required to achieve and maintain inhibition, and its loss turns c-Abl into an oncogenic protein and contributes to deregulation of BCR-Abl.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.