A novel case of infantile sacral teratoma and a constitutional t(12;15)(q13;q25) pat.

There is no fulltext present in this item.

Title:	A novel case of infantile sacral teratoma and a constitutional t(12;15)(q13;q25) pat.
Author(s):	Veltman, I.M.; Asseldonk, M.G.J. van; Schepens, M.T.M.; Stoop, H.; Looijenga, L.H.J.; Wouters, C.W. ; Govaerts, L.C.P.; Suijkerbuijk, R.F. ; Geurts van Kessel, A.H.M.
Publication year:	2002
Source:	Cancer Genetics and Cytogenetics, vol. 136, iss. 1, (2002), pp. 17-22
ISSN:	0165-4608
DOI:	https://doi.org/10.1016/S0165-4608(01)00666-5
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/186475
Display more details
Subject:	Chromosomal aberrations and cancer Chromosomale aberraties en kanker
Organization:	Human Genetics Gynaecology
Journal title:	Cancer Genetics and Cytogenetics
Volume:	vol. 136
Issue:	iss. 1
Page start:	p. 17
Page end:	p. 22
Abstract:	Cytogenetic analysis of peripheral lymphocytes of an infantile patient with a sacral teratoma revealed a constitutional translocation (12;15)(q13;q25) pat. The same translocation was found in four additional relatives. Loss of heterozygosity analysis of the patient's tumor material showed retention of both translocation-derived chromosomes. Since allelic loss in the 12q13 region has been observed in germ cell tumors, we hypothesize that disregulation of genes located at or near the 12q13 breakpoint may be related to the development of this sacral teratoma. As a first step towards the identification of these genes, a 12q13 genomic contig that spans the breakpoint has been constructed.