Ethnic variations in uterine leiomyoma biology are not caused by differences in myometrial estrogen receptor alpha levels.
SourceJournal of the Society for Gynecologic Investigation, 10, 2, (2003), pp. 105-9
Article / Letter to editor
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Journal of the Society for Gynecologic Investigation
SubjectUMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 5.2: Endocrinology and reproduction
OBJECTIVE: Uterine leiomyomas develop in women of reproductive age and regress after menopause, suggesting that they grow in a steroid hormone-dependent fashion. Furthermore, it is widely accepted that symptomatic uterine leiomyomas occur at a twofold to threefold higher frequency in black women than in white women. The present study was designed to investigate a possible physiologic role of racial differences in the myometrial estrogen receptor alpha in this phenomenon. METHODS: We compared the expression of the estrogen receptor and progesterone receptor in myometrium by ligand-binding assay and the estrogen receptor alpha by real-time polymerase chain reaction in women from different ethnic backgrounds who have uterine leiomyoma. RESULTS: Estrogen receptor and progesterone receptor concentrations and estrogen receptor alpha transcription levels were not statistically different between ethnic backgrounds. CONCLUSION: Neither on a transcriptional nor on a protein level were there statistically relevant differences in steroid hormone receptor levels. A causative role for these receptors in the ethnic variation of leiomyoma biology seems unlikely.
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