Capillarization and vascular endothelial growth factor expression in hypertrophying anterior latissimus dorsi muscle of the Japanese quail.
Publication year
2003Source
Advances in Experimental Medicine and Biology, 530, (2003), pp. 577-85ISSN
Publication type
Article / Letter to editor
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Organization
Physiology
Journal title
Advances in Experimental Medicine and Biology
Volume
vol. 530
Page start
p. 577
Page end
p. 85
Subject
UMCN 2.2: Vascular medicine and diabetesAbstract
Hypertrophy may increase the diffusion distances from capillaries to the interior of the muscle fibers. We hypothesized that capillary proliferation occurs during hypertrophy, which is accompanied by an up-regulation of vascular endothelial growth factor (VEGF). Hypertrophy of the left anterior latissimus dorsi muscle of Japanese quail (2-3 months old) was induced by 1-4 week stretch-overload. Capillarization was analyzed in cross-sections stained for ATPase. VEGF expression was determined with RT-PCR. Initially, hypertrophy was not accompanied by increases in fiber cross-sectional area (FCSA), but after 1 week the average FCSA did increase. The capillary to fiber ratio was decreased after 1 week, but returned to control values in subsequent weeks. This indicates that capillary proliferation occurred, because this model is characterized by extensive fiber proliferation. The absence of any significant change in VEGF mRNA levels indicates that increased levels of VEGF mRNA are not crucial for capillary proliferation during muscle hypertrophy.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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