Sensory gating in rats: Lack of correlation between auditory evoked potential gating and prepulse inhibition
SourceSchizophrenia Bulletin, 25, 4, (1999), pp. 777-788
Article / Letter to editor
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SW OZ DCC BI
SubjectEffects of antipsychotics in an animal model of negative symptoms of schizophrenia; Effecten van antipsychotica in een diermodel voor negatieve symptomen van schizofrenie
This study was designed to evaluate the possible similarities between two paradigms designed to Tmeasure sensory gating: (1) an auditory evoked potential (AEP), called the P50 gating paradigm: and (2) an acoustic startle (ASR), called the prepulse inhibition paradigm. These paradigms show a number of methodological pharmacological, and neurobiological similarities, and they are both disturbed in patients with schizophrenia. In the first of three experiments, the AEP gating and the ASR gating were measured in rats. Although both AEP and ASR gating could readily be obtained, there appeared to be no correlation between the performance in these two paradigms.This lack of correlation was confirmed using a factor analytical approach, where the AEP gating and the ASR gating parameters were found to load on different factors. In the second experiment, the interstimulus interval in the ASR paradigm was increased to 500 ms (identical to the interstimulus interval of the AEP gating paradigm. This increase reduced the degree of ASR gating, although some gating could still be obtained. Again no correlation was found between AEP and ASR gating, and this was again confirmed by the factorial analysis. In the final experiment, the effects of the dopamine D2/3 agonist 7-OHDPAT were evaluated in both paradigms. This selective agonist dose dependently reduced ASR gating but had no effect on AEP gating. Together, these data strongly suggest that AEP and ASR gating measure two different aspects of information processing and indicate that both paradigms may be important for investigating the nuerobiological disturbances observed in patients with psychoses. Key words: Sensory gating, auditory evoked potential, acoustic startle.
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