The effect of insemination/injection time on the results of IVF and ICSI.

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Title:	The effect of insemination/injection time on the results of IVF and ICSI.
Author(s):	Jacobs, M.; Stolwijk, A.M. ; Wetzels, A.M.M.
Publication year:	2001
Source:	Human Reproduction, vol. 16, iss. 8, (2001), pp. 1708-1713
ISSN:	0268-1161
Related links:	http://humrep.oupjournals.org/cgi/content/abstract/16/8/1708
DOI:	http://dx.doi.org/10.1093/humrep/16.8.1708
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/185798
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Subject:	Prevention of disorders in human reproduction: (Patho)Physiological, endocrinological and methabolic aspects Preventie van stoornissen in de menselijke voortplanting: (Patho-)fysiologische, endocriene en metabole aspecten.
Organization:	Health Evidence Gynaecology
Journal title:	Human Reproduction
Volume:	vol. 16
Issue:	iss. 8
Page start:	p. 1708
Page end:	p. 1713
Classification:	Acid-Base ImbalanceBrainBrain DiseasesCulture MediaEstrogensFemale Genital Diseases and Pregnancy Complications (Non MeSH)Fertility Agents, FemaleFertilization in VitroFetal DiseasesFetal DistressFetal MonitoringFetusGonadotropinsInfertilityPregnancy ComplicationsReproductionReproduction TechniquesReproductive Control Agents (Non MeSH)Sleep
Abstract:	BACKGROUND: The aim of this study was to investigate whether a pre-incubation time between oocyte retrieval and insemination or injection had any effect on the success rate of IVF or intracytoplasmic sperm injection (ICSI). Based on previously published data, many laboratories retain a time interval of several hours between oocyte retrieval and insemination/injection. In our setting, insemination and injection times are dependent only on the laboratory workload. METHODS: Totals of 881 IVF and 432 ICSI cycles performed between 1997 and 1999 were analysed retrospectively. Oocyte retrieval occurred 36 h after human chorionic gonadotrophin administration, and insemination or injection took place 1--7 or 0.5--8 h after oocyte retrieval respectively. RESULTS: No statistically significant differences were found between these time periods and outcome of IVF and ICSI with respect to fertilization rate, embryo quality, implantation rate, abortion and ongoing pregnancy rates, except for the abortion rate after IVF. As this finding may be due to chance and no differences were found in the ongoing pregnancy rates, this finding was considered to be of less importance. CONCLUSIONS: If laboratory control and efficiency demands early insemination or injection, it could be performed without reservation.