Antioxidants reduce oxidative stress in claudicants.
SourceJournal of Surgical Research, 96, 2, (2001), pp. 183--7
Article / Letter to editor
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Journal of Surgical Research
SubjectSepsis and non-bacterial generalized inflammation: causes and effects (sepsis and inflammation); Sepsis en niet-bacteriële gegeneraliseerde ontsteking: mogelijke oorzaken en gevolgen (sepsis en ontsteking)
BACKGROUND: Low-grade ischemia-reperfusion in claudicants leads to damage of local tissues and remote organs. Since this damage is partly caused by oxygen-derived free radicals (ODFR), scavenging these ODFR could reduce the local and remote injury. METHODS: Using a new method by which a free radical reaction product (ortho-APOH) of the exogenous marker antipyrine is measured to quantify the oxidative stress, 16 stable claudicants performed a standard walking test before and after administration of vitamin E (200 mg) and vitamin C (500 mg) daily for 4 weeks. FINDINGS: Ortho-APOH was significantly increased during the reperfusion period (P = 0.026) before administration of the vitamins. After 4 weeks of vitamin supplementation no rise was found in the reperfusion period. Malondialdehyde showed no changes in either group. INTERPRETATION: These findings indicate that administering extra antioxidants to claudicants reduces oxidative stress in these patients. This may also have an effect on the remote ischemia-reperfusion damage and reduce cardiovascular morbidity in this group.
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