BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining.

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Title:	BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining.
Author(s):	Scheepers, P.T.J. ; Coggon, D.; Knudsen, L.E.; Anzion, R.B.M. ; Autrup, H.; Bogovski, S.; Bos, R.P. ; Dahmann, D.; Farmer, P.; Martin, E.A.; Micka, V.; Muzyka, V.; Neumann, H.G.; Poole, J.; Schmidt-Ott, A.; Seiler, F.; Volf, J.; Zwirner-Baier, I.
Publication year:	2002
Source:	Toxicology Letters, vol. 134, iss. 1-3, (2002), pp. 305-317
ISSN:	0378-4274
DOI:	https://doi.org/10.1016/S0378-4274(02)00195-9
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/185262
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Subject:	Epidemiology Metabolism and Toxicology Epidemiologie Metabolisme en Toxicologie
Organization:	Health Evidence Pharmacology-Toxicology
Journal title:	Toxicology Letters
Volume:	vol. 134
Issue:	iss. 1-3
Page start:	p. 305
Page end:	p. 317
Abstract:	Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of susceptibility was also explored. Underground workers (drivers of diesel-powered excavators) at an oil shale mine in Estonia were compared with surface workers. Personal exposures to particle-associated 1-nitropyrene (NP) were some eight times higher underground than on the surface. Underground miners were also occupationally exposed to benzene and polycyclic aromatic hydrocarbons, as indicated by excretion of urinary metabolites of benzene and pyrene. In addition, increased O(6)-alkylguanine DNA adducts were detected in the white blood cells of underground workers, suggesting higher exposure to nitroso-compounds. However, no differences between underground and surface workers were observed in the levels of other bulky DNA adducts determined by 32P-postlabelling, or in DNA damage. The study indicated that smoking, diet and residential indoor air pollution are important non-occupational factors to consider when interpreting biomonitoring results.