BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining.
Publication year
2002Source
Toxicology Letters, 134, 1-3, (2002), pp. 305-317ISSN
Publication type
Article / Letter to editor

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Organization
Health Evidence
Pharmacology-Toxicology
Journal title
Toxicology Letters
Volume
vol. 134
Issue
iss. 1-3
Page start
p. 305
Page end
p. 317
Subject
Epidemiology; Metabolism and Toxicology; Epidemiologie; Metabolisme en ToxicologieAbstract
Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of susceptibility was also explored. Underground workers (drivers of diesel-powered excavators) at an oil shale mine in Estonia were compared with surface workers. Personal exposures to particle-associated 1-nitropyrene (NP) were some eight times higher underground than on the surface. Underground miners were also occupationally exposed to benzene and polycyclic aromatic hydrocarbons, as indicated by excretion of urinary metabolites of benzene and pyrene. In addition, increased O(6)-alkylguanine DNA adducts were detected in the white blood cells of underground workers, suggesting higher exposure to nitroso-compounds. However, no differences between underground and surface workers were observed in the levels of other bulky DNA adducts determined by 32P-postlabelling, or in DNA damage. The study indicated that smoking, diet and residential indoor air pollution are important non-occupational factors to consider when interpreting biomonitoring results.
This item appears in the following Collection(s)
- Academic publications [203812]
- Faculty of Medical Sciences [80326]
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