Vorozole (R83842) in the treatment of postmenopausal advanced breast cancer: relationship of serum levels of vorozole and clinical results (a study of the EORTC Breast Cancer Cooperative Group)
SourceAnti-Cancer Drugs, 9, (1998), pp. 419-425
Article / Letter to editor
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SubjectExperimental diagnostics and therapy of malignancies
The new non-steroidal aromatase inhibitor vorozole (R83842) was administered orally at a single daily dose of 2.5 mg to 27 postmenopausal women with advancest breast cancer in a phase II trial as second-line endocrine treatment. The observed objective response rate of 30% and good tolerability of the drug confirm other recent reports. Endocrine determinations during 6 months of treatment demonstrated reduction of serum estrogens: etrone sulfate by more than 60%, estrone by 30-40%, but estradiol by only 10-20%....
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