Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age.
Publication year
2002Source
Journal of Neuroimmunology, 133, 1-2, (2002), pp. 30-8ISSN
Publication type
Article / Letter to editor
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Organization
Psychoneuropharmacology
CSS
Cognitive Neuroscience
Journal title
Journal of Neuroimmunology
Volume
vol. 133
Issue
iss. 1-2
Page start
p. 30
Page end
p. 8
Subject
Pharmacotherapy of psychomotor diseases; fundamental and applied research; Farmacotherapie van psychomotorische ziektebeelden; fundamenteel en toegepast onderzoekAbstract
Maternal deprivation of neonatal animals has been shown to induce long-lasting changes in the reactivity of the neuroendocrine system. The aim of the present study was to investigate whether maternal deprivation also affects susceptibility to immune-mediated diseases such as experimental autoimmune encephalomyelitis (EAE) in adult life.To this end, 9-day-old rat pups were subjected to a short-lasting maternal deprivation for a period of 24 h. At the age of 8 weeks, we induced EAE in these rats by immunization with myelin basic protein (MBP) in complete Freund's adjuvant. Our data demonstrate that short-lasting maternal deprivation induces a marked increase in the severity of EAE in the animals in later life. The histopathological evaluation of spinal cord and cerebellum corresponded with the observed differences in clinical symptoms of EAE. Moreover, neonatal maternal deprivation affects macrophage functioning at adult age. In contrast, no differences were observed in in vitro mitogen- and MBP-induced cytokine production by splenocytes. LPS-induced corticosterone release did not differ either between maternally deprived and control animals. We conclude that short-lasting neonatal maternal deprivation of rat pups has long-lasting consequences for macrophage activity and for susceptibility to the inflammatory autoimmune disease EAE.
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- Academic publications [245054]
- Faculty of Medical Sciences [93209]
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