Making Heads or Tails of It: Cell-Cell Adhesion in Cellular and Supracellular Polarity in Collective Migration
SourceCold Spring Harbor Perspectives in Biology, 9, 11, (2017), article a027854
Article / Letter to editor
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Cell Biology (UMC)
Cold Spring Harbor Perspectives in Biology
SubjectRadboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences
Collective cell migration is paramount to morphogenesis and contributes to the pathogenesis of cancer. To migrate directionally and reach their site of destination, migrating cells must distinguish a front and a rear. In addition to polarizing individually, cell-cell interactions in collectively migrating cells give rise to a higher order of polarity, which allows them to move as a supracellular unit. Rather than just conferring adhesion, emerging evidence indicates that cadherin-based adherens junctions intrinsically polarize the cluster and relay mechanical signals to establish both intracellular and supracellular polarity. In this review, we discuss the various functions of adherens junctions in polarity of migrating cohorts.
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