Microstructured beta-Tricalcium Phosphate Putty Versus Autologous Bone for Repair of Alveolar Clefts in a Goat Model
until further notice
SourceCleft Palate-Craniofacial Journal, 54, 6, (2017), pp. 699-706
Article / Letter to editor
Display more detailsDisplay less details
Oral and Maxillofacial Surgery
Cleft Palate-Craniofacial Journal
SubjectRadboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences
For the first time it was demonstrated that an osteoinductive calcium phosphate-based putty is effective in the restoration of complex maxillofacial defects. In these defects, adequate mechanical confinement by multiple bony walls and osteoconduction from multiple surfaces are usually lacking. This study compares the efficacy of a microstructured beta-tricalcium phosphate (beta-TCP) putty with autologous bone for the repair of alveolar cleft defects. A total of 10 Dutch milk goats were operated on in a split-mouth study design in which two-wall bony alveolar clefts were created and successively repaired with autologous bone (the gold standard) at one side and beta-TCP putty at the other. After 24 weeks of implantation, histomorphometric and micro-computer tomography analyses proved that the beta-TCP putty group showed equal bone quality and volume to clefts reconstructed with autologous bone. In addition, surgical handling of the putty is superior to the use of calcium phosphates in a granular form. Therefore, the results of this study open a clear trajectory for the clinical use of beta-TCP putty in the reconstruction of the alveolar cleft and other challenging two-wall bony defects.
Upload full text
Use your RU credentials (u/z-number and password) tolog in with SURFconextto upload a file for processing by the repository team.