Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders

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Title:	Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders
Author(s):	Post, R.S. van der; Carneiro, F.
Publication year:	2017
Source:	Surgical Pathology Clinics, vol. 10, iss. 4, (2017), pp. 931-945
ISSN:	1875-9181
DOI:	https://doi.org/10.1016/j.path.2017.07.011
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/182293
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Subject:	Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Pathology
Journal title:	Surgical Pathology Clinics
Volume:	vol. 10
Issue:	iss. 4
Page start:	p. 931
Page end:	p. 945
Abstract:	Hereditary gastric cancer is a relatively rare disease with specific clinical and histopathologic characteristics. Hereditary gastric cancer of the diffuse type is predominantly caused by germline mutations in CDH1. The inherited cause of familial intestinal gastric cancer is unknown. Gastric adenocarcinoma and proximal polyposis of the stomach is a hereditary cancer syndrome caused by germline mutations in promoter 1B of APC. Other well-defined cancer syndromes, such as Lynch, Li-Fraumeni, and hereditary breast or ovarian cancer syndromes, are associated with increased risk of gastric cancer. This article reviews important histopathologic features and emerging concepts regarding gastric carcinogenesis in these syndromes.