Oral submucous fibrosis: An update on pathophysiology of malignant transformation
SourceJournal of Oral Pathology & Medicine, 46, 6, (2017), pp. 413-417
Article / Letter to editor
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Oral and Maxillofacial Surgery
Journal of Oral Pathology & Medicine
SubjectRadboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.
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