Automatic detection of the foveal center in optical coherence tomography
SourceBiomedical Optics Express, 8, 11, (2017), pp. 5160-5178
Article / Letter to editor
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Biomedical Optics Express
SubjectRadboudumc 12: Sensory disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
We propose a method for automatic detection of the foveal center in optical coherence tomography (OCT). The method is based on a pixel-wise classification of all pixels in an OCT volume using a fully convolutional neural network (CNN) with dilated convolution filters. The CNN-architecture contains anisotropic dilated filters and a shortcut connection and has been trained using a dynamic training procedure where the network identifies its own relevant training samples. The performance of the proposed method is evaluated on a data set of 400 OCT scans of patients affected by age-related macular degeneration (AMD) at different severity levels. For 391 scans (97.75%) the method identified the foveal center with a distance to a human reference less than 750 mum, with a mean (+/- SD) distance of 71 mum +/- 107 mum. Two independent observers also annotated the foveal center, with a mean distance to the reference of 57 mum +/- 84 mum and 56 mum +/- 80 mum, respectively. Furthermore, we evaluate variations to the proposed network architecture and training procedure, providing insight in the characteristics that led to the demonstrated performance of the proposed method.
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