Modification of automatic alcohol-approach tendencies in alcohol-dependent patients with mild or major neurocognitive disorder
until further notice
Number of pages
SourceAlcoholism-Clinical and Experimental Research, 42, 1, (2018), pp. 153-161
Article / Letter to editor
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SW OZ DCC NRP
SW OZ BSI KLP
Alcoholism-Clinical and Experimental Research
SubjectDI-BCB_DCC_Theme 3: Plasticity and Memory; Experimental Psychopathology and Treatment; Neuropsychology and rehabilitation psychology; Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical Neuroscience; Neuro- en revalidatiepsychologie
Background: To examine the applicability of an alcohol-avoidance training procedure in patients with alcohol dependence and alcohol-induced neurocognitive disorders, we trained two groups that differed in the degree of cognitive impairment: One group fulfilled the DSM-5 criteria for Alcohol-Induced Mild Neurocognitive Disorder, and one group was diagnosed with Korsakoff's syndrome (Alcohol-Induced Major Neurocognitive Disorder, Confabulatory/Amnesic subtype; DSM-5). The intervention is assumed to match the preserved cognitive capacity for implicit learning in both groups. Methods: 51 Inpatients with a mild neurocognitive disorder and 54 inpatients with Korsakoff's syndrome were trained. Six training sessions (including pre- and posttests) of a computerized implicit alcohol approach-avoidance task were applied. Neurocognitive variables were available from the standard assessment procedure of the clinic. Results: Training of alcohol-avoidance tendencies is feasible in a population with alcohol-related neurocognitive disorders. The alcohol-approach bias decreased for both groups in each session. Better learning results over time were obtained in participants with a larger baseline alcohol-approach tendency. Learning effects were positively related to age and implicit (non-declarative) memory functioning. No relation between training effects and executive or explicit memory functions were found. Conclusions: Training of an alcohol avoidance tendency can be successfully applied in patients with alcohol-dependence including those with alcohol-induced neurocognitive disorders.
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