Hyper-responsivity to losses in the anterior insula during economic choice scales with depression severity
Source
Psychological Medicine, 47, 16, (2017), pp. 2879-2891ISSN
Publication type
Article / Letter to editor
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Organization
SW OZ BSI KLP
PI Group Affective Neuroscience
Journal title
Psychological Medicine
Volume
vol. 47
Issue
iss. 16
Languages used
English (eng)
Page start
p. 2879
Page end
p. 2891
Subject
Experimental Psychopathology and TreatmentAbstract
Commonly observed distortions in decision-making among patients with major depressive disorder (MDD) may emerge from impaired reward processing and cognitive biases toward negative events. There is substantial theoretical support for the hypothesis that MDD patients overweight potential losses compared with gains, though the neurobiological underpinnings of this bias are uncertain. Twenty-one unmedicated patients with MDD were compared with 25 healthy controls (HC) using functional magnetic resonance imaging (fMRI) together with an economic decision-making task over mixed lotteries involving probabilistic gains and losses. Region-of-interest analyses evaluated neural signatures of gain and loss coding within a core network of brain areas known to be involved in valuation (anterior insula, caudate nucleus, ventromedial prefrontal cortex). Usable fMRI data were available for 19 MDD and 23 HC subjects. Anterior insula signal showed negative coding of losses (gain > loss) in HC subjects consistent with previous findings, whereas MDD subjects demonstrated significant reversals in these associations (loss > gain). Moreover, depression severity further enhanced the positive coding of losses in anterior insula, ventromedial prefrontal cortex, and caudate nucleus. The hyper-responsivity to losses displayed by the anterior insula of MDD patients was paralleled by a reduced influence of gain, but not loss, stake size on choice latencies. Patients with MDD demonstrate a significant shift from negative to positive coding of losses in the anterior insula, revealing the importance of this structure in value-based decision-making in the context of emotional disturbances.
This item appears in the following Collection(s)
- Academic publications [246164]
- Donders Centre for Cognitive Neuroimaging [4036]
- Faculty of Social Sciences [30430]
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