Reported associations between receptor genes and human sociality are explained by methodological errors and do not replicate
Number of pages
SourceProceedings of the National Academy of Sciences USA, 114, 44, (2017), pp. E9185-E9186
Article / Letter to editor
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SW OZ BSI OGG
Proceedings of the National Academy of Sciences USA
Using a sample of 757 British individuals, Pearce et al. (1) tested 24 single-nucleotide polymorphisms (SNPs) in six candidate genes for association with eight social behavior traits. For each SNP for each trait, five genotypic model tests were reported (except the androgen receptor gene, for which two model tests were reported), resulting in 936 reported tests. Of these, 44 (4.7%) were significant at P < 0.05, a proportion of significant associations that would be expected by chance if there was no true association between the SNPs and the traits measured in this dataset.
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