The Impact of Central and Peripheral Cyclooxygenase Enzyme Inhibition on Exercise-Induced Elevations in Core Body Temperature.
SourceInternational Journal of Sports Physiology and Performance, 12, 5, (2017), pp. 662-667
1 mei 2017
Article / Letter to editor
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International Journal of Sports Physiology and Performance
SubjectRadboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 6: Metabolic Disorders RIHS: Radboud Institute for Health Sciences
PURPOSE: Exercise increases core body temperature (TC) due to metabolic heat production. However, the exercise-induced release of inflammatory cytokines including interleukin-6 (IL-6) may also contribute to the rise in TC by increasing the hypothalamic temperature set point. This study investigated whether the exercise-induced increase in TC is partly caused by an altered hypothalamic temperature set point. METHODS: Fifteen healthy, active men age 36 +/- 14 y were recruited. Subjects performed submaximal treadmill exercise in 3 randomized test conditions: (1) 400 mg ibuprofen and 1000 mg acetaminophen (IBU/APAP), (2) 1000 mg acetaminophen (APAP), and (3) a control condition (CTRL). Acetaminophen and ibuprofen were used to block the effect of IL-6 at a central and peripheral level, respectively. TC, skin temperature, and heart rate were measured continuously during the submaximal exercise tests. RESULTS: Baseline values of TC, skin temperature, and heart rate did not differ across conditions. Serum IL-6 concentrations increased in all 3 conditions. A significantly lower peak TC was observed in IBU/APAP (38.8 degrees C +/- 0.4 degrees C) vs CTRL (39.2 degrees C +/- 0.5 degrees C, P = .02) but not in APAP (38.9 degrees C +/- 0.4 degrees C) vs CTRL. Similarly, a lower DeltaTC was observed in IBU/APAP (1.7 degrees C +/- 0.3 degrees C) vs CTRL (2.0 degrees C +/- 0.5 degrees C, P < .02) but not in APAP (1.7 degrees C +/- 0.5 degrees C) vs CTRL. No differences were observed in skin temperature and heart-rate responses across conditions. CONCLUSIONS: The combined administration of acetaminophen and ibuprofen resulted in an attenuated increase in TC during exercise compared with a CTRL. This observation suggests that a prostaglandin-E2-induced elevated hypothalamic temperature set point may contribute to the exercise-induced rise in TC.
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