Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET
Publication year
2017Source
European Journal of Nuclear Medicine and Molecular Imaging, 44, Suppl 1, (2017), pp. 4-16ISSN
Publication type
Article / Letter to editor
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Organization
Medical Imaging
Journal title
European Journal of Nuclear Medicine and Molecular Imaging
Volume
vol. 44
Issue
iss. Suppl 1
Page start
p. 4
Page end
p. 16
Subject
Radboudumc 0: Other Research RIHS: Radboud Institute for Health SciencesAbstract
In recent years, there have been multiple advances in positron emission tomography/computed tomography (PET/CT) that improve cancer imaging. The present generation of PET/CT scanners introduces new hardware, software, and acquisition methods. This review describes these new developments, which include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent 18F-fluorodeoxyglucose (FDG) activity. Also, hardware developments such as continuous bed motion (CBM), (digital) solid-state photodetectors and combined PET and magnetic resonance (MR) systems are explained. These novel techniques have a significant impact on cancer imaging, as they result in better image quality, improved small lesion detectability, and more accurate quantification of radiopharmaceutical uptake. This influences cancer diagnosis and staging, as well as therapy response monitoring and radiotherapy planning. Finally, the possible impact of these developments on the European Association of Nuclear Medicine (EANM) guidelines and EANM Research Ltd. (EARL) accreditation for FDG-PET/CT tumor imaging is discussed.
This item appears in the following Collection(s)
- Academic publications [238586]
- Electronic publications [122822]
- Faculty of Medical Sciences [90409]
- Open Access publications [97808]
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