Publication year
2017Source
Journal of Hypertension, 35, 9, (2017), pp. 1849-1856ISSN
Publication type
Article / Letter to editor
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Organization
Internal Medicine
Health Evidence
Laboratory Medicine
Pharmacology-Toxicology
Journal title
Journal of Hypertension
Volume
vol. 35
Issue
iss. 9
Page start
p. 1849
Page end
p. 1856
Subject
Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences; Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences; Health Evidence Radboud University Medical Center; Internal Medicine Radboud University Medical Center; Laboratory Medicine Radboud University Medical Center; Pharmacology-Toxicology Radboud University Medical CenterAbstract
BACKGROUND: The incidence of cardiovascular events is higher in patients with primary aldosteronism than in patients with essential hypertension (EHT), despite similar blood pressure levels. This suggests detrimental cardiovascular effects of aldosterone. Amongst others, it has been suggested that galectin-3 (Gal-3) is a key mediator in aldosterone-induced myocardial fibrosis. OBJECTIVE: We studied whether patients with primary aldosteronism have higher plasma Gal-3 concentrations than patients with EHT and evaluated its reversibility after adrenalectomy. METHODS: In a retrospective cohort from our tertiary referral centre, we measured plasma Gal-3 concentrations in 78 patients with primary aldosteronism, 39 cured primary aldosteronism patients after adrenalectomy and 56 patients with EHT. Paired samples were available in 11 patients (preadrenalectomy and postadrenalectomy). We compared plasma Gal-3 levels by univariate analysis of covariance with correction for cardiovascular risk factors, plasma creatinine concentration, plasma potassium levels and alcohol intake. RESULTS: Adjusted plasma Gal-3 concentrations in patients with primary aldosteronism, patients after adrenalectomy and patients with EHT were 11.39 +/- 0.60, 11.64 +/- 0.81 and 11.41 +/- 0.73 ng/ml, respectively (mean +/- SD; P = 0.95). In 11 patients of whom paired samples were available, mean Gal-3 concentrations increased from 10.03 +/- 1.67 ng/ml preadrenalectomy to 14.36 +/- 2.07 ng/ml postadrenalectomy (P < 0.01). CONCLUSION: In patients with primary aldosteronism, plasma Gal-3 concentrations are not elevated when compared with patients with EHT, and levels do not decrease after adrenalectomy. These results are in contrast to previous studies and do not support a pathophysiological role of plasma Gal-3 in the increased cardiovascular risk in patients with primary aldosteronism.
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- Faculty of Medical Sciences [93209]
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