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Title: Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations
Author(s): Muilwijk, E.W. ; Dekkers, B.G.J.; Henriet, S.S.V. ; Verweij, P.E. ; Witjes, B.; Lashof, A.; Groeneveld, G.H.; Hoeven, J.G. van der ; Alffenaar, J.W.C.; Russel, F.G. ; Veerdonk, F.L. van de ; Bruggemann, R.J.M.
Publication year: 2017
Source: Antimicrobial Agents and Chemotherapy, vol. 61, iss. 9, (2017), article e00915-17
ISSN: 0066-4804
DOI: https://doi.org/10.1128/AAC.00915-17
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/177025   https://hdl.handle.net/2066/177025

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Subject: Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Clinical Pharmacy
Paediatrics
Paediatrics - OUD tm 2017
Medical Microbiology
Intensive Care
Pharmacology-Toxicology
Internal Medicine
Journal title:
Antimicrobial Agents and Chemotherapy
Volume: vol. 61
Issue: iss. 9
Article number: e00915-17
Abstract:
Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

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