Publication year
2017Source
Clinical Science, 131, 12, (2017), pp. 1191-1206ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Donders Centre for Cognitive Neuroimaging
Journal title
Clinical Science
Volume
vol. 131
Issue
iss. 12
Page start
p. 1191
Page end
p. 1206
Subject
Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of dementia. Comprehensive characterization of the time course of disease progression will result in better understanding of aetiology and clinical consequences of SVD. SVD progression has been studied extensively over the years, usually describing change in SVD markers over time using neuroimaging at two time points. As a consequence, SVD is usually seen as a rather linear, continuously progressive process. This assumption of continuous progression of SVD markers was recently challenged by several studies that showed regression of SVD markers. Here, we provide a review on disease progression in sporadic SVD, thereby taking into account both progression and regression of SVD markers with emphasis on white matter hyperintensities (WMH), lacunes and microbleeds. We will elaborate on temporal dynamics of SVD progression and discuss the view of SVD progression as a dynamic process, rather than the traditional view of SVD as a continuous progressive process, that might better fit evidence from longitudinal neuroimaging studies. We will discuss possible mechanisms and clinical implications of a dynamic time course of SVD, with both progression and regression of SVD markers.
This item appears in the following Collection(s)
- Academic publications [202923]
- Donders Centre for Cognitive Neuroimaging [3357]
- Faculty of Medical Sciences [80072]
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