[Influence of smoking on pharmacokinetics of medication]
SourceNederlands Tijdschrift voor Geneeskunde, 161, 0, (2017), article D939
Article / Letter to editor
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Nederlands Tijdschrift voor Geneeskunde
SubjectRadboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
- In a previous issue, a case report was presented in the Dutch Journal of Medicine (NTvG) of a patient who had variable clozapine levels after switching from regular cigarettes to an e-cigarette and vice versa.- Besides clozapine there are a number of other agents with a narrow therapeutic range where pharmacokinetics can be influenced by smoking.- This review describes the mechanisms of smoking-induced influence on the pharmacokinetics of medicines, and guidance will be provided regarding which medicines must be monitored more closely when patients change their smoking habits.- Finally, an overview is given on package insert information concerning dose adjustments for smokers and non-smokers.
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