Subject:
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Molecular Structure and Dynamics Radboudumc 0: Other Research RIMLS: Radboud Institute for Molecular Life Sciences Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc |
Organization:
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Molecular Structure and Dynamics Paediatrics Paediatrics - OUD tm 2017 Laboratory Medicine |
Abstract:
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Small molecule identification is a continually expanding field of research and represents the core challenge in various areas of (bio)analytical science, including metabolomics. Here, we unequivocally differentiate enantiomeric N-acetylhexosamines in body fluids using infrared ion spectroscopy, providing orthogonal identification of molecular structure unavailable by standard liquid chromatography/high-resolution tandem mass spectrometry. These results illustrate the potential of infrared ion spectroscopy for the identification of small molecules from complex mixtures.
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